In Vivo Histocompatibility Evaluation of Polyurethane Membrane Modified by Su...

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In Vivo Histocompatibility Evaluation of Polyurethane Membrane Modified by Superfine Silk-fibroin Powder
欧阳晨曦[1] 许海叶[2] 王维慈[1] 杨红军[3] 徐卫林[2][1]Department of Vascular Surgery, Union Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wu- han 430022, China [2]Key Laboratory of Green Processing and Functional Textiles under Ministry of Education, Wuhan University of Science and En- gineering, Wuhan 430073, China [3]College of Textile, Donghua University, Shanghai 201620, China

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关键词:聚氨酯薄膜 组织相容性 蛋白粉 超细丝 膜改性 丝素 聚四氟乙烯材料 评价
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In Vivo Histocompatibility Evaluation of Polyurethane Membrane Modified by Superfine Silk-fibroin PowderChenxi OUYANG , Haiye XU , Weici WANG , Hongiun YANG, Weilin XU 1Department of Vascular Surgery, Union Hospital, Tongii Medical College, Huazhong University of Science and Technology, Wuhan 430022, China 2Key Laboratory of Green Processing and Functional Textiles under Ministry of Education, Wuhan University of Science and Engineering, Wuhan 430073, China 3College of Textile, Donghua University, Shanghai 201620, ChinaAbstract:In this study, a novel polyurethane membrane, modified by superfine silk-fibroin powder, was prepared for small-diameter vascular grafting. Scanning electron microscopy, transmission electron microscopy, and histological examination were applied to evaluate histocompatibility of this polyurethane membrane. The polyurethane membrane was compared with polytetrafluoroethylene material. A pseudomembrane and gap formed between polytetrafluoroethylene and the surrounding tissues, and no cells infiltrated or grew into the polytetrafluoroethylene material. On the contrary, superfine silk-fibroin powder/polyurethane blend membrane merged tightly with the surrounding tissues without gaps, and cells infiltrated and grew into the material. Moreover, the negative effects of superfine silk-fibroin powder/polyurethane blend membrane on cells were less than those of its polytetrafluoroethylene counterpart. Our findings indicated that the superfine silk-fibroin powder/polyurethane blend membrane has better histocompatibility than polytetrafluoroethylene membrane. It is concluded that the superfine silk-fibroin powder/polyurethane blend membrane is a promising biomaterial for small-diameter prosthesis.[著者文摘]

Key words:polyurethane; superfine silk-fibroin powder; polytetrafluoroethylene; histocompatibility