远程氧等离子体灭菌对基质材料表面性能的影响

PTFE

远程氧等离子体灭菌对基质材料表面性能的影响
刘红霞[1,2] 陈杰瑢[1][1]西安交通大学环境科学与工程系,西安710049 [2]西安交通大学动力工程多相流国家重点实验室,西安710049

摘　要:在特定的远程氧等离子体灭菌条件下，通过接触角测定、质量损失率计算、微生物培养和体外凝血实验，考察了染菌载体医用聚四氟乙烯（PTFE）表面的物理、化学及医学使用性能在灭菌前、后发生的变化，并通过X射线光电子能谱进行了表面分析．结果表明：远程氧等离子体灭菌在载体PTFE膜表面引入了含氧极性基团并取代了F元素，从而使PTFE表面的亲水性在距放电中心0～40cm范围内得到明显增强，且随距离的增加，表面受损程度得到了有效抑制；PTFE膜表面的生物相容性在灭菌后有较大幅度的增强，并在距放电中心40cm处获得了最佳改善效果；亲水性是影响PTFE表面生物相容性好坏的关键因素，而与刻蚀度没有特定关系，只有当亲水性与刻蚀度达到最佳的平衡状态时，才能使生物相客性得到最大程度的改善．[著者文摘]

关键词:远程氧等离子体 灭菌 医用聚四氟乙烯 表面性能
分类号:　O631[著者标引]文献标识码：A文章编号：0253-987X（2009）03-0082-05栏目信息：专题研究
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Influence of Remote Oxygen Plasma Sterilization on Surface Property of Substrate MaterialLIU Hongxia, CHEN Jierong 1. Department of Environmental Science and Engineering, Xi＇an Jiaotong University, Xi＇an 710049, China; 2. State Key Laboratory of Multlphase Flow in Power Engineering, Xi＇an Jiaotong University, Xi＇an 710049, ChinaAbstract:Under the given conditions of remote oxygen plasma sterilization, the physical, chemical and medical properties of sterilized poly（tetrafluoroethylene） （PTFE） surface are investigated by water contact angle measurement, mass loss calculation, microorganism incubation and blood coagulation measuration in vitro, respectively. The surface analysis is characterized by X-ray photoelectron spectroscopy. The results show that remote oxygen plasma sterilization can induce polar oxygen functionalities onto the PTFE film surface to replace the F element, making the surface hydrophilicity enhanced within the distance of 0-40 cm from the center of plasma discharge. With the distance increasing, the surface damage of PTFE is restrained. The surface biocompatibility of remote oxygen plasma-sterilized PTFE film is also strengthened to a great extent, and the optimal effect can be obtained at the distance of 40 cm. Surface hydrophilicity is the pivotal factor for influencing the biocompatibility, while surface etching has no special relationship with it. Only when＇ the optimal equilibrium is obtained between surface hydrophilicity and etching could the biocompatibility achieve the maximum improvement.[著者文摘]

Key words:remote oxygen plasma; sterilization; poly（tetrafluoroethylene） ; surface property