膨体聚四氟乙烯作为创面覆盖材料的实验观察

PTFE

膨体聚四氟乙烯作为创面覆盖材料的实验观察
Experimental Observation on ePTFE as a safe Material Covering Wound Surface
作　　者：田田[1] 李英春[1] 周斌[2]

TIAN Tian, LI Ying-chun, ZHOU Bin （ The Cosmetic Center, the Second Affiliated Clinical Hospital of Yangzhou University, Jiangsu 225001, China ）

机构地区：[1]江苏省扬州大学第二临床医学院扬州市第一人民医院美容中心,江苏扬州225001 [2]扬州大学医学院,江苏扬州225001

出　　处：《医学临床研究》 CAS 2008年第25卷第1期 7-9页,共3页

Journal of Clinical Research

摘　　要：【目的】探讨高分子材料膨体聚四氟乙烯作为创面覆盖材料的可行性。【方法】取SD大鼠皮肤和修剪好的膨体聚四氟乙烯材料移植于成年Wistar大鼠，移植成功后逐日肉眼观察创面愈合情况并取不同时间点标本用HE染色法光镜下观察组织切片中巨噬细胞，成纤维细胞，淋巴细胞的数量。并与自体移植组、异体移植组比较。【结果】膨体聚四氟乙烯材料覆盖于创面后，与创面附着牢固，未见炎症等不良反应，局部组织中巨噬细胞，成纤维细胞，淋巴细胞数量显著低于同种异体皮肤移植组。【结论】膨体聚四氟乙烯只具有很弱的炎症反应及异物反应，长期放在受损创面上不会引起不良反应。可以考虑将其作为创面覆盖材料。

[Objective] To assess the feasibility of high molecular expensive polytetrafiuorioethylene （ePTFE） as a safe material covering wound surface. [Methods]The back skin of the SD rats and clipped ePTFE were implanted into the back of Wistar rats. The healing process of wound surface was observed daily, and representative specimens were obtained at different time point. Tissue sections were stained with H＆E and examined under light microscope. The number of macrophages, fibroblasts and lymphocytes were enumerated and compared with those in the control group of allograft. [Results] ePTFE adhered tightly to the wound surface. Inflammation and other adverse effects were not observed throughout the experiment. The number of macrophages, fibroblasts and lymphocytes in the study group were significantly lower than those in the control group （ P 〈0. 01）. [Conclusion] ePTFE has minimal inflammatory response and foreign body reaction. It will unlikely to cause adverse effects when placed on the wound surface for a long time, therefore ePTFE can be used as a safe material covering the wound surface.

关 键 词：聚四氟乙烯
polytetrafluoroethylene
分 类 号： R318.08 [医药、卫生 > 基础医学 > 医用一般科学 > 生物医学工程 > 一般性问题]

参考文献作者在撰写文献时引用的其他文献，反映本文的背景或依据。 (5篇)[1]吴志谷.创伤修复材料[J].中国实用外科杂志,:.
[2]龚非力.医学免疫学[M] 第2版[M].北京:北京科技出版社,2004.144-163.
[3]金蓉 吴晓军 谈宇腾 等.膨体聚四氟乙烯鼻整形287例体会[J].中国美容整形外科杂志,2007,18(6):178-179.
[4]张洁 李东 李健宁.膨体聚四氟乙烯用于组织工程支架材料的实验研究[J].中国美容医学,2003,(5):456-457.
[5]路会 刘庆阳 高占巍.降低e P T F E隆鼻术后感染发生率的临床研究[J].中国美容医学,2006,15(6):677-678.