Affinity Adsorption of Bilirubin on Cibacron Blue F3GA-modified Microporous P...

聚四氟乙烯

Affinity Adsorption of Bilirubin on Cibacron Blue F3GA-modified Microporous Polytetrafluoroethylene Capillary
JIN Gu YAO Jian-xiaDepartment of Chemistry, University of Science and Technology of China, Hefei 230026, P. R. China

摘　要:
关键词:F3GA 聚四氟乙烯 Cibacron 亲和吸附 胆红素 毛细管 微孔 甲基丙烯酸缩水甘油酯
分类号:　TQ613 TQ325.4[机标]文献标识码：文章编号：1005-9040（2010）-02-323-08栏目信息：
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Affinity Adsorption of Bilirubin on Cibacron Blue F3GA-modified Microporous Polytetrafluoroethylene CapillaryAbstract:Bilirubin removal from human plasma was obtained via an affinity microporous polytetrafluoroethylene（MPTFE） capillary. The new adsorbent comprised grafted glycidyl methacrylate（GMA） via radiation-induced polymerization as hydrophilic coating and reactive sites; ethylenediamine（EDA） as a spacer arm; Cibacron Blue F3GA（CB F3GA） as an affinity ligand; MPTFE capillary as the supporting matrix. The average density of CB F3GA attachment to MPTFE capillaries was found to be 136.5 μmol/g. The capacity of bilirubin adsorbed on affinity MPTFE capillaries is 76.1 mg bilirubin/g polymer（at 25℃）. This new adsorbent has advantages over both membrane and traditional micro-column, and this system is stable and easy to operate. The results of blood tests suggest the CB F3GA affinity capillary has good blood compatibility.[著者文摘]

Key words:Bilirubin removal; Radiation grafting; Cibacron Blue F3GA; Polytetrafluoroethylene; Microporous capillary